Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing

SD Jamadar; F Sforazzini; P Raniga; NJ Ferris; B Paton; MJ Bailey; A Brodtmann; PA Yates; GA Donnan; SA Ward; RL Woods; E Storey; JJ McNeil; GF Egan

Journal article

Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing

SD Jamadar, F Sforazzini, P Raniga, NJ Ferris, B Paton, MJ Bailey, A Brodtmann, PA Yates, GA Donnan, SA Ward, RL Woods, E Storey, JJ McNeil, GF Egan

Journals of Gerontology Series B Psychological Sciences and Social Sciences | OXFORD UNIV PRESS INC | Published : 2019

DOI: 10.1093/geronb/gby004

Abstract

Objectives: The onset of many illnesses is confounded with age and sex. Increasing age is a risk factor for the development of many illnesses, and sexual dimorphism influences brain anatomy, function, and cognition. Here, we examine frequency-specific connectivity in resting-state networks in a large sample (n = 406) of healthy aged adults. Method: We quantify frequency-specific connectivity in three resting-state networks known to be implicated in age-related decline: the default mode, dorsal attention, and salience networks, using multiband functional magnetic resonance imaging. Frequency-specific connectivity was quantified in four bands: low (0.015-0.027 Hz), moderately low (0.027-0.073 ..

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University of Melbourne Researchers

Amy Brodtmann Author

Geoffrey Donnan Author

Paul Andrew Yates Author

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ARC CENTRE OF EXCELLENCE FOR INTEGRATIVE BRAIN FUNCTION

The Centre of Excellence for Integrative Brain Function will address one of the greatest scientific challenges of the 21st century â€“ to un..

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by an Australian National Health and Medical Research Council Project Grant (APP1086188). ASPREE was supported by the National Institutes of Health (grant number U01AG029824); the National Health and Medical Research Council of Australia (grant numbers 334047, 1127060); Monash University (Australia) and the Victorian Cancer Agency (Australia). GE and SJ are supported by the Australian Research Council (ARC) Centre of Excellence for Integrative Brain Function (CE140100007). SJ is supported by an ARC Discovery Early Career Researcher Award (DE150100406). The Principal ASPREE study is registered with the International Standardized Randomized Controlled Trials Register, ASPirin in Reducing Events in the Elderly, Number: ISRCTN83772183 and clinicaltrials.gov number NCT01038583. ASPREE-Neuro trial is registered with Australian New Zealand Clinical Trials Registry ACTRN12613001313729.